The University of Louisville entered Big East Conference Tournament play as the nation's hottest team, winning 16 straight, and as the prohibitive favorite, but that all came to an end on day one in Clearwater, Fla.
The Cardinals fell to the 8th-seeded Connecticut Huskies 3-2 in 12 innings on Wednesday.
After grabbing a 2-1 lead after in the first inning, the Cardinals couldn't find an offensive spark for the remainder of the contest. U of L managed just 3 hits for the next 11 innings.
Louisville now faces the difficult task of playing in the loser's side of the bracket in the double-elimination tournament.
U of L will face host South Florida on Thursday at 5:00pm.