The victory propelled the 5th-ranked Cardinals to the finals of the WNIT where they fill face No. 11 Oklahoma in Norman.
Just three games back from a hip injury that sidelined her all of last season, Taylor's effort established a new career high and marked her fourth career double-double.
"I felt great out there," Taylor said.
Following a redshirt season, the fifth-year senior is off to a great start, averaging 15.6 points and 7 rebounds through three games.
"It's a long time coming," she said. "It's five years in the making right here. It's just working hard. I work on it every day in practice. My teammates, that's why that have confidence in me."
The Cardinals built an early 9-point first half lead, but the 14th-ranked Tigers clawed their way back and held a one-point lead with 2:06 remaining before the break.
The lead was short-lived as senior Shoni Schimmel scored on an acrobatic layup and followed it was a three-pointer to give the Cardinals a 40-36 halftime lead.
"To be honest, I was just playing basketball," Schimmel said. "I wasn't thinking about anything and just enjoying it. It just came natural."
Schimmel, a preseason Wooden Top 30 List selection, finished with 15 points on 7 of 11 shooting.
Louisville blew the game open with a 21-0 run midway through the second half. Holding a 60-54 lead with 10:53 remaining in the game, U of L expanded it's lead to 27 before the Tigers managed another score.
Head coach Jeff Walz credited his team's defensive rebounding efforts for creating, "fast break after fast break."
"We needed everybody to defensive rebound," Walz explained. "That's what we keep telling every body. Everybody has to go to the glass, you've got to rebound."
The Cardinals won the battle on the boards 45-33.
The Cardinals received 12 points from Antonita Slaughter and 11 points each from Sara Hammond and Bria Smith.
Louisville will face Oklahoma for the preseason WNIT title on Sunday, Nov., 17. The game will be broadcast on the CBS Sports Network.