Shoni Schimmel had a season-high 30 points and Bria Smith added 13 as No. 7 Louisville handed No. 11 Colorado its first loss of the season with a 69-62 win Saturday.
Bria Smith added 13 points for the Cardinals, while Asia Taylor had seven points and seven rebounds and Sara Hammond added six points and eight rebounds.
Lexy Kresl led Colorado with 17 points. The loss ended Colorado's streak of 33 straight victories in nonconference, regular-season games.
A layup from Colorado's Brittany Wilson closed the gap to 65-62 with 24 seconds left. Schimmel, who was 13 of 16 from the free-throw line, made two free throws and a layup to close out Louisville's fifth straight win and improve to 12-1.
Kresl had nine of the Buffaloes' first 12 points and her 3-pointer gave Colorado its first lead, 8-5. Louisville rallied and went ahead 16-12 on a three-pointer by Schimmel.
On two straight possessions, Asia Taylor twice completed a three-point play after being fouled while making a layup, bolstering Louisville's advantage to 22-16 midway through the first half.
Jude Schimmel's two straight layups closed out the first half to give Louisville a 33-29 lead at the break.
The game remained close throughout the second half, with no team leading by more than five points until Louisville broke it open with a 7-0 run to go up 53-46.