Gardner connected for his team-high fifth home run in the first inning, driving in two to give the hosts a quick 2 run lead. Gardner plated his 16th RBI of the season with a double in the fifth to give U of L a comfortable 6-0 advantage.
Freshman Drew Harrington started on the mound and picked up the win after tossing four scoreless innings and striking out five.
Louisville has now won 8 straight against Ohio State and leads the overall series 10-3.
Up next for Louisville is an important conference series at South Florida. At 11-4 in AAC play, the Cardinals enter the weekend in second place, one game back of Central Florida (12-3).
Visit the Omaha Room to join in the baseball discussion.