Despite Louisville jumping out to an early 14-0 lead with less than half of the first quarter gone, the host Houston Cougars stayed close enough throughout the next two and half quarters to give the Cardinals some concern. However, after pulling within 35-27 with 14:12 remaining in the contest, the visiting 8th-ranked Cardinals lit up the scoreboard with 23 unanswered points to win by a convincing 65-27 margain.
With the victory the 8-1 Cardinals now claim at least a share of the Conference USA title, the school's third C-USA crown.
Louisville was lead once again by a near perfect Stefan LeFors, who despite throwing his first interception with the season opener against Kentucky, completed 82% of his pass attempts for 317 yards and three touchdowns.
The Cardinals ground game dominated the fourth quarter and finished the game with 242 yards, led by Eric Shelton's 87 yards and three touchdowns.
The Cardinal defense strengthened as the game wore on and limited the Houston offense to just 71 yards on the ground, while also recording four sacks and an interception.
Joshua Tinch led the Cardinal receivers with 5 catches for 148 yards and a score, while J.R. Russell pulled in 7 receptions for 99 yards. Tight end Adam McCauley added two touchdown receptions.
Defensively, the Cardinals were led by linebacker Robert McCune, who once again led the team with tackles, recording 13 on the night. With two sacks on the night, senior defensive end Marcus Jones raised his career sack total to 22.
Louisville will next face rival Cincinnati on Saturday, November 27th at Papa John's Cardinal Stadium in the annual battle for the Keg of Nails.
NOTES:The 65 points scored by the Cardinals is the most ever by one team in a league contest. Louisville held the previous record of 64 in a 1997 victory over Tulane.
Louisville's 666 total yards is the fifth best single game performance in school history.
With three more touchdowns on Saturday, Eric Shelton now has 26 career rushing scores, moving him into 4th all-time at U of L. Shelton trails Lenny Lyles 43 scores and Frank Moreau and Anthony Shelman, both of whom recorded 27 career touchdowns.