Red-shirt center Eric Wood and Mario Urrutia made their first career starts for the Cardinals. On defense, sophomore Matt Sanders, and juniors Brandon Sharp and Gavin Smart also made their first career starts.
Head coach Bobby Petrino is 3-0 in season openers as head coach of the Cardinals and is 7-0 in the month of September.
With Brian Brohm's first quarter touchdown run, the Cardinals extended their streak of consecutive game's with a rushing touchdown to 22.
On the game's first drive, sophomore quarterback Brian Brohm, making his first career start, directed the Cardinals on a 13-play, 76-yard drive which ended in a one-yard Brohm run. It was Brohm's third career touchdown run. He added another one in the second quarter on a one-yard run.
Senior wide receiver Joshua Tinch caught a pass in the first quarter to extend his streak to 17 games with a reception.
The Cardinals played just one true freshman in Lamar Alston.
Senior Elvis Dumervil set a new school record for sacks in a game with six, breaking the old mark of five by Mike Flores against Murray State in 1990.
Junior Michael Bush registered his fourth career 100-yard rushing performance gaining 128 yards on a career-high 27 carries. The junior also recorded two second quarter touchdowns.